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Choe M, Einav T, Phillips R, Titov DV. Data-driven model of glycolysis identifies the role of allostery in maintaining ATP homeostasis.

Kukurugya MA, Titov DV. The Warburg Effect is the result of faster ATP production by glycolysis than respiration.

Choe M, Titov DV. Genetically encoded tools for measuring and manipulating metabolism. Nature Chemical Biology. 2022 May;18(5):451–460.

Rivera-Lugo R, Deng D, Anaya-Sanchez A, Tejedor-Sanz S, Reyes Ruiz VM, Smith HB,Titov DV, Sauer JD, Skaar EP, Ajo-Franklin CM, Portnoy DA, and Light SH. Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis. eLife. 2022 Apr 5;11:e75424. (bioRxiv. 2021)

Yang X, Heinemann M, Howard J, Huber G, Iyer-Biswas S, Le Treut G, Lynch M, Montooth KL, Needleman DJ, Pigolotti S, Rodenfels J, Ronceray P, Shankar S, Tavassoly I, Thutupalli S, Titov DV, Wang J, and Foster PJ. Physical bioenergetics: Energy fluxes, budgets, and constraints in cells. PNAS. 2021 Jun 29;118(26):e2026786118. (PDF)

Manford AG, Rodriguez-Perez F, Shih KY, Shi Z, Berdan CB, Choe M, Titov DV, Nomura DK, Rape M. A cellular mechanism to detect and alleviate reductive stress. Cell. 2020 Oct 1;183(1):46-61.

Mick E, Titov DV, Skinner OS, Sharma R, Jourdain AA, Mootha VK. Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell. eLife. 2020 May 28;9. (PDF)

Cracan V*, Titov DV*, Shen H, Grabarek Z, Mootha VK. Genetically encoded tool for manipulation of NADP+/NADPH ratio. Nature Chemical Biology. 2017 Oct;13(10):1088-1095. (PDF)

Titov DV*, Cracan V*, Goodman RP, Peng J, Grabarek Z, Mootha VK. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.  Science. 2016 Apr 8;352(6282):231-5. (PDF)

Lewis-Smith D, Kamer KJ, Griffin H, Childs AM, Pysden K, Titov D, Duff J, Pyle A, Taylor RW, Yu-Wai-Man P, Ramesh V, Horvath R, Mootha VK, Chinnery PF. Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood. Neurology Genetics. 2016 Mar 3;2(2):e59. (PDF)

He QL*, Titov DV*, Li J, Tan M, Ye Z, Zhao Y, Romo D, Liu JO. Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide. Angewandte Chemie International Edition. 2015 Feb 2;54(6):1859-63. (PDF)

Titov DV, Liu JO. Identification and validation of protein targets of bioactive small molecules. Bioorganic & Medicinal Chemistry. 2012 Mar 15; 20(6):1902-9. (PDF)

Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nature Chemical Biology. 2011 Mar; 7(3):182-8. (PDF)

Liu JO, Titov DV, Dang Y, He Q. Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP. Molecular Cell. 2011 Jan 21; 41(2):131-3. (PDF)

Ni Q, Titov DV, Zhang J. Analyzing protein kinase dynamics in living cells with FRET reporters. Methods. 2006 Nov;40(3):279-86. (PDF)

*  – these authors contributed equally to this work

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