Welcome to the Titov Lab website. Our laboratory is based in the Departments of Molecular & Cell Biology, Nutritional Sciences & Toxicology, and the Center for Computational Biology at the University of California, Berkeley.
Our lab aims to understand how metabolic homeostasis is achieved and how caloric restriction extends lifespan. We are interested in the following broad questions: How do cells maintain ATP homeostasis? How do metabolic pathways coordinate conflicting goals of ATP production and biosynthesis? How does diet extend lifespan and delay the onset of age-associated diseases? Can we predict the diet that will increase the lifespan of an individual animal?
In order to tackle these questions we are using a combination of biochemistry, mathematical modeling, physiology, custom instrumentation and novel tool development to study metabolism and aging in mammalian cell culture and model organisms.