Welcome to the homepage of the Titov Lab. Our laboratory is based in the Department of Molecular & Cell Biology and the California Institute for Quantitative Biosciences at the University of California, Berkeley.
The long-term goal of our laboratory is to understand the molecular basis of inactivation of cellular machinery during aging. We are interested in addressing the following broad questions: What are the molecular mechanisms of age-associated damage to proteins, nucleic acids and lipids? Why do some damaged components get repaired, while others accumulate? How do environmental factors like diet and exercise modulate the rate of accumulation of age-associated damage?
In order to tackle these questions we are using a combination of biochemistry, physiology, mathematical modeling and novel tool development to study aging in cell culture and model organisms.